Network pharmacology and experimental evidence of the anti-colorectal cancer potential of Xian Lian Jie Du formula: quercetin, kaempferol and luteolin jointly inhibit the HIF1A/IL6/TNF oncogenic pathway
Colorectal cancer (CRC) is still one of the main reasons for death from cancer worldwide. Xian Lian Jie Du decoction (XLJD) is based on Professor Zhou Zhongying’s idea of “tumour toxins”, and it has shown some therapeutic effects in CRC; however, its active ingredients and specific molecular targets are not yet fully k...