A hippocampal-lateral posterior thalamic nucleus neural circuit mediates cognitive impairment and metabolic dysfunction in male mice with type 2 diabetes.
OBJECTIVES Type 2 diabetes mellitus (T2DM) is a multisystem disorder characterized by metabolic dysregulation and cognitive decline. While hippocampal dysfunction is a recognized feature of cognitive impairment, upstream neural circuits that couple peripheral metabolic signals to central cognition remain poorly defined...