Exploring ULK family in human cancer: insights into mechanisms and therapeutic potential.
The ULK (Unc-51-like kinase) family, a group of serine/threonine protein kinases, plays a central regulatory role in the initiation of autophagy. Autophagy has a dual role in cancer, as it can both inhibit tumor formation and promote the survival and progression of established tumors, making targeting autophagy an attr...