Author

Xinyi Zheng

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Open access Jul 2026

Integrated single-cell and spatial transcriptomics reveals a multicellular program contributing to immunotherapy resistance and adverse clinical outcomes in clear cell renal cell carcinoma.

This study defines a spatially organized, functionally coordinated multicellular niche that drives ICB resistance in ccRCC, establishing both a predictive biomarker for patient stratification and a mechanistic framework for therapeutic intervention.

Wen-Bin Yao, Jia Qi, Xinyi Zheng et al. · npj Precision Oncology · 0 citations

Review Aug 2026

Biomimetic delivery systems for overcoming drug resistance in gastrointestinal cancers.

By linking GI cancer-focused MDR biology to function-oriented biomimetic design, this review establishes an evidence-based framework for distinguishing delivery enhancement from true MDR reversal and outlines platform-specific requirements for clinical translation.

Gou Wu, Aixue Li, Yongwei Gu et al. · Drug resistance updates · 0 citations