Author

Xinyu Xue

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Open access Sep 2026

Exploring the targets and mechanisms of 6PPD-Q-induced cardiotoxicity: A network toxicology and molecular docking study.

6PPD-quinone (6PPD-Q), a transformation product of the tire antioxidant 6PPD, is an emerging traffic-related contaminant with well-documented ecotoxicity in aquatic species. Its recent detection in airborne particulate matter, road dust, and human urine has raised concerns about possible human health effects. However,...

Ai-Mei Lu, Kai-Lin Huang, Meng-Fan Li et al. · Ecotoxicology and Environmen... · 0 citations

Review Open access Jul 2026

Mitochondrial dysfunction-driven PANoptosis in doxorubicin-induced cardiotoxicity: mechanistic insights and intervention strategies

Doxorubicin (DOX) is a broad-spectrum anthracycline chemotherapeutic agent, and its clinical application is severely limited by dose-dependent cardiotoxicity (DIC), for which there are currently no effective clinical interventions. Mitochondria are the central organelles regulating myocardial energy metabolism and cell...

Xin-Yu Xue, Xi-Han Liao, Xing Ji et al. · Frontiers in Pharmacology · 0 citations