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Author

Xiong-Jian Rao

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2 papers indexed here

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Review Oct 2026

Non-histone protein lactylation in cancer metastasis: From metabolic reprogramming to therapeutic targeting.

Cancer metastasis remains the leading cause of cancer-related mortality, and tumor metabolic reprogramming, particularly aerobic glycolysis and lactate accumulation, is increasingly recognized as a metastatic driver. Lysine lactylation provides a direct mechanism by which lactate modifies proteins to shape tumor behavi...

Mithu Howlader, A. Akinyemi, Md Rakibul Alam et al. · 0 citations
Open access Sep 2026

CDK1-mediated phosphorylation of APE1 drives synthetic lethality, p53-dependent metastasis, and immune sensitization in NSCLC

Cyclin-dependent kinase 1 (CDK1), a serine/threonine kinase essential for cell cycle progression, also plays critical roles in DNA damage response, gene expression regulation, and therapeutic resistance. In this study, we identify a previously unrecognized regulatory link between CDK1 and apurinic/apyrimidinic endonu...

Jian-Lin Wang, Jiang Li, Jia Peng et al. · 0 citations

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