Xiong-Wei Fan

Loss of wbp11 causes multi-system developmental defects: a zebrafish model of VACTERL association

Introduction VACTERL association is a congenital disorder characterized by the non-random co-occurrence of vertebral, anal, cardiac, tracheo-esophageal, renal, and limb anomalies. WBP11 has been identified as a candidate causative gene; however, existing heterozygous Wbp11 knockout mice recapitulate only a subset of th...