Author

Xiu-Hong Wu

3 papers indexed here

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Review Open access Oct 2026

Metabolites as key signaling mediators: rethinking diabetic kidney disease from a network perspective

Diabetic kidney disease (DKD) remains the leading cause of end-stage renal disease worldwide. Current diagnostic approaches rely mainly on albuminuria and eGFR, but these are insufficiently sensitive for detecting early lesions, and treatment options remain limited. Metabolites are not merely byproducts of metabolism b...

Xin Li, Xu Wang, Cheng Fang et al. · Frontiers in Endocrinology · 0 citations

Oct 2026

Discovery of the mechanism of Huangqi Guizhi Wuwu Decoction in the treatment of Diabetic Peripheral Neuropathy with Qi Deficiency and Blood Stasis based on the dynamic metabolic trajectory analysis.

HGWD significantly improved neurological function and alleviated pathological damage in the DPN rat model and provides a comprehensive strategy for deciphering the mechanisms of Traditional Chinese Medicine formulas and support the potential application of HGWD in DPN treatment.

Jing Wen, Li Yan, Yu-Jie Xiang et al. · Journal of Ethnopharmacology · 0 citations

Sep 2026

Colonic administration of baitouweng decoction alleviates ulcerative colitis via coordinated reprogramming of arginine and tryptophan metabolism.

BACKGROUND Ulcerative colitis (UC) involves persistent colonic inflammation, loss of epithelial barrier integrity, and disturbed immune regulation. Although Baitouweng decoction (BTW) is widely used for intestinal inflammatory disorders, the effects and mechanisms of colon-targeted administration remain unclear. PURP...

Lin Ding, Xu Wang, Ting-Ting Liu et al. · Phytomedicine · 0 citations