Author

Xiu-Hua Guo

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Oct 2026

Childhood loneliness and deficit-accumulation frailty progression in mid-to-late life.

BACKGROUND Adult loneliness has been linked to various age-related conditions, yet the long-term consequences of childhood loneliness remain poorly understood. This study examined the association between childhood loneliness and frailty progression in mid-to-late adulthood. METHODS We analyzed data from 13,643 partic...

Jin-Qi Wang, Dan-Yang Jiao, Xiao-Yu Zhao et al. · Archives of gerontology and... · 0 citations

Open access Sep 2026

Depressive Symptoms Trajectories Across the Transition to Cardiovascular Disease in Middle-Aged and Older Adults: A Multicohort Study.

Depressive symptoms show a gradual increase before CVD diagnosis, elevate further around the time of diagnosis, and continue to worsen thereafter, calling for the integration of mental health screening and management into CVD care at all stages, from primary prevention to long-term disease management.

Jiao Wang, Zhi-Yuan Wu, Xin-Ye Zou et al. · European Journal of Preventi... · 0 citations

Review Open access Aug 2026

Association of the Pan-Immune-Inflammation Value-to-Albumin Ratio as a Novel Cardiovascular Disease Predictor in Type 2 Diabetes: A Prospective Cohort Study

Objectives: Individuals with type 2 diabetes (T2D) remain at high cardiovascular disease (CVD) risk. The pan-immune-inflammation value (PIV) integrates circulating neutrophils, monocytes, platelets, and lymphocytes but does not capture albumin-related nutritional and inflammatory reserve. We investigated associations b...

Fang-Kun Liu, Xing-Hua Yang, Bo Gao et al. · Biomedicines · 0 citations