Author

Xiuwen Wu

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Open access Sep 2026

scH16S‐Seq Maps Klebsiella pneumoniae‐Associated Myeloid States and Reveals a CD38–NAD Immunometabolic Axis That Impairs Lysosomal Acidification in Sepsis

ABSTRACT Sepsis arises from heterogeneous host‐cell states that influence bacterial clearance, yet single‐cell transcriptomic approaches do not directly connect microbial signals with host transcriptional programs. This study introduces single‐cell host–bacterial 16S co‐sequencing (scH16S‐seq), which couples host trans...

Yang-Guang Li, Yi-Long Yu, Fang Qin et al. · Advancement of science · 0 citations

#artificial intelligence Review Open access Sep 2026

Combating antimicrobial resistance through multimodal data via artificial intelligence

Antimicrobial resistance (AMR) poses a critical global health challenge, leading to substantial mortality and economic losses without science-based interventions. Conventional approaches to combating AMR have important limitations in addressing this escalating threat. Recent advances in AI, including deep learning, lar...

Qiu-Hua Xia, Jia-Yang Li, Wen-Qi Wu et al. · One Health · 0 citations