X. Zhao

Lipoic acid-conjugated chalcones exert antitumor activity via ROS elevation and ferroptosis.

Overcoming drug resistance and minimizing off-target toxicity remain major challenges in cancer therapy. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a promising therapeutic target. Natural chalcones exhibit antitumor properties linked to oxidative stress indu...