Open access
Jul 2026
Tubular PFKFB3 drives diabetic kidney fibrosis via lactate-dependent H4K12 lactylation and HIPK2 transactivation
Aerobic glycolysis is increasingly recognized as a pathogenic driver in diabetic kidney disease (DKD). However, the epigenetic role of its end product, lactate, remains largely undefined. Spatial transcriptomics analysis revealed active glycolysis in tubular epithelial cells. The participation of histone lactylation in...
Mingkun Xu, Linhang Fu, Yulong Zhang et al.
· International Journal of Mol... · 0 citations