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Xiumin Shi

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Jun 2026

Prot-ΔΔG: Prediction of protein–protein binding affinity changes upon mutations with pre-training strategies

Prot-ΔΔG is introduced, a purely sequence-based deep learning framework that integrates large-scale pre-trained protein language models with a BiGRU-DBRNN encoder that effectively captures evolutionary and context-dependent patterns without relying on structural inputs.

Han Zhou, Yuxiang Wang, Xiumin Shi et al. · 0 citations