Xu-Hui Liu

Heterogeneous human muscle fibroadipogenic progenitors include a DLK1+ subpopulation that prevents fatty infiltration after injury.

This work defined molecularly distinct, clinically relevant human FAP subpopulations, established DLK1 as a regulator of adipogenic potential in vivo, and provided a framework to identify pathogenic FAP states that may be used in the pursuit to prevent maladaptive muscle remodeling.