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Xu-Rui Shen

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Open access Oct 2026

Natural variation in BtSARSr-CoV nsp12 harbors adaptive mutations that enhance viral replication and spillover risk in humans

ABSTRACT The non-structural protein 12 (nsp12) is essential for SARS-related coronavirus (SARSr-CoV) replication and a major antiviral target, yet the functional significance of its natural variation in bat reservoirs remains unclear. Here, by analyzing 183 bat SARS-related coronavirus nsp12 sequences, we identified mu...

Ang Li, Hao-Rui Si, Ke Wu et al. · 0 citations

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