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Sep 2026

JQ-1 attenuates microglial activation and retinal pathology in experimental diabetic retinopathy with modulation of Pagr1a/JAK2/STAT3 signaling.

Diabetic retinopathy (DR) is a major vision-threatening complication of diabetes mellitus, in which chronic inflammation and retinal microglial activation contribute to disease progression. Bromodomain-containing protein 4 (BRD4) is an epigenetic regulator involved in inflammatory transcription; however, the downstream...

Ran Wang, Li-Wen Wang, Xu Sun et al. · 0 citations
Open access Aug 2026

Disruption of the AR/ZNF217/PROM2 axis sensitizes prostate cancer to ferroptosis and enzalutamide therapy

Dysregulation of androgen receptor (AR) signaling is a key molecular driver of prostate cancer development and its transition to castration-resistant disease. Although emerging evidence indicates that AR may influence ferroptosis by modulating lipid peroxidation and antioxidant systems, the complete transcriptional n...

Wenjun Hao, Peng Liang, Wanglong Zheng et al. · 0 citations

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