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Xu Wang

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Open access Sep 2026

Multi-Omics Mendelian Randomization Maps Lipid-Related Brain Cell-Type Associations with Kidney Disease

Background: Cellular heterogeneity limits causal inference in complex diseases. We applied an established cell-type-stratified Mendelian randomization (csMR) framework, originally developed by Hao et al. (2024), to investigate whether lipid phenotypes affect kidney disease through distinct brain cell populations, exten...

Jia-Ni Deng, Bo-Ning Cao, Feng-Jie Zheng et al. · 0 citations
Open access Jan 2026

Mechanistic Elucidation of Yiqi Yangyin Qingre Decoction in Diabetic Nephropathy Therapy via Network Pharmacology and In Vivo Validation

YQYYQR exerts a protective effect against DN progression by targeting core genes including GSK3β, regulating the GSK3β‐TFEB axis to restore autophagic flux via the autophagy‐lysosomal pathway, and inhibiting NLRP3‐mediated pyroptosis to mitigate excessive renal inflammation.

Shu-Jiao Zhang, Yiran Xie, Jingyi Tang et al. · 0 citations

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