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Author

Xu-Wen Li

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Review Sep 2026

Pyridones and macrocyclic pyrrolidones from marine fungal PKS-NRPS hybrids: biosynthetic origin, bioactivities, and synthetic advances.

A roadmap for future genome-guided discovery and the rational design of novel therapeutics inspired by these privileged marine natural products is provided, covering their global distribution and biosynthetic enzymology, chemical ecology, and biosynthesis.

Ning Gao, F. Owusu, Jie Yu et al. · 0 citations
Sep 2026

Function-oriented synthesis of marine phidianidine derivatives as potent anti-MRSA agents.

Mechanistic study showed that 24a effectively inhibits biofilm formation and exerts its antibacterial effect by disrupting the bacterial cell membrane, paving the way for new strategies to combat antimicrobial resistance.

Qiong Wu, Bing-Yuan Yan, Chen Qu et al. · 0 citations

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