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Xu Yang

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Open access Sep 2026

Targeting mitochondrial EGFR by CTAB in triple-negative breast cancer

EGFR is an oncogenic factor highly expressed in multiple tumor types. While previous research has primarily focused on plasma membrane-localized EGFR, the role of its mitochondrial localization (mitoEGFR) in breast cancer remains poorly understood. This study reveals that EGFR is enriched in mitochondria in triple-ne...

Yuan-Zhen Li, Si-Yuan Yang, Xu Yang et al. · 0 citations
Sep 2026

WTAP-mediated m6A modification upregulates the circCDK8 to promote ferroptosis in periodontal ligament stem cells.

Investigating the role of WTAP in LPS-induced ferroptosis in PDLSCs reveals that WTAP drives ferroptosis in PDLSCs through m6A-dependent stabilization of circCDK8, which activates the let-7a-5p/TFRC and YBX1/ACSL4 axes, offering mechanistic insights for alveolar bone repair.

Xu Yang, Pei-Kun Shi · 0 citations

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