Open access
Sep 2026
USP4‐Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC
ABSTRACT Durable responses to current therapies remain limited in hepatocellular carcinoma (HCC), highlighting the need to identify regulators of malignant progression. By integrating multi‐omics analyses, spatial transcriptomics, clinical specimens, and multiple models, we identified chromatin assembly factor 1B (CHAF...
Sai-Yan Bian, Yun Tong, Wen-Kai Ni et al.
· Advancement of science · 0 citations