Akkermansia muciniphila Ameliorates Midlife Obesity-Induced Cognitive Impairment via the Microbiota-Metabolism-Neuroinflammation Axis
Midlife obesity is an established independent risk factor for age-related cognitive decline, yet direct causal experimental evidence and underlying gut microbial mechanisms remain poorly defined. Using a mouse model of high-fat diet (HFD)-induced obesity restricted to the midlife period (6–12 months of age) in male wil...