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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Xuan Liu

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Open access Sep 2026

6PPDQ Promotes Cutaneous Squamous Cell Carcinoma Growth with PI3K-Akt/MMP9 Activation: Evidence from Integrated Network Toxicology and Experimental Investigation

N-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPDQ) are emerging tire-derived environmental contaminants, showing a potential tumor-promoting effect. However, their relevance to cutaneous squamous cell carcinoma (cSCC) remains unclear. Here, we used network toxi...

De-Kun Song, Yu-Lu Chen, Yue Wu et al. · 0 citations

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