Aug 2026
MLN4924 Enhances RSL3-Induced Ferroptosis Sensitivity in Glioblastoma via Inhibiting the STAT3/GPX4 Axis.
GPX4 is identified as the principal mediator of MLN4924-induced ferroptosis and dual targeting of GPX4 transcription and activity represents a promising therapeutic strategy for GBM, establishing that dual targeting of GPX4 transcription and activity represents a promising therapeutic strategy.
Zhou Jing, Fangyuan Wang, Hao Li et al.
· Carcinogenesis · 0 citations