Author

Xudong Guo

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Open access Oct 2026

Repurposing ritonavir to induce proteasomal degradation of IE1 for inhibition of human cytomegalovirus replication.

Human cytomegalovirus (HCMV) is a major pathogen affecting immunocompromised individuals. Current antiviral drugs target the mid-to-late stages of viral replication but are limited by toxicity and drug resistance. The IE1 protein serves as a key early regulator of HCMV replication; however, it has long been considered...

Wan-Feng Liu, Yu Shi, Xu-Dong Guo et al. · PLoS Computational Biology · 0 citations

Jul 2026

Language Model-Enhanced Geometric Learning for Metalloprotein Pathogenic Mutations.

MetalDiagnosis is proposed, a deep learning framework that integrates an improved equivariant graph neural network with a pre-trained protein language model to predict disease-associated mutation sites in metal-binding proteins and employs a sliding-window strategy to extract deep contextual semantic information from t...

Xudong Guo, Runchang Jia, Heyun Sun et al. · IEEE journal of biomedical a... · 0 citations