Review
Open access
Aug 2026
NLRP3 inflammasome in acute kidney injury: molecular mechanisms, post-translational regulation, and immunotherapeutic potential
This review elucidates the molecular composition of the NLRP3 inflammasome, its canonical and non-canonical activation pathways, and integrates the critical roles of post-translational modifications in regulating its activation, as well as their specific activation mechanisms across distinct subtypes of AKI.
Ming-Ru Ma, Man-Ling Zhang, Hong-Fei Sun et al.
· Frontiers in Immunology · 0 citations