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Author

Xue Cai

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Review Open access Sep 2026

Soluble CTLA-4 as a context-dependent immune checkpoint: biology, biomarker potential, and therapeutic implications

Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) exists not only as a membrane-bound immune checkpoint but also as a naturally secreted soluble isoform (sCTLA-4), generated primarily through exon 3 skipping. This review focuses specifically on splice-derived sCTLA-4 and examines its biological and clinical signific...

Xue Cai, Li-Hua Yu, Xiao-Li Liu et al. · 0 citations

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