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Author

Xue-Fang Huang

2 papers indexed here

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Review Oct 2026

Lipid metabolic regulation and targeting strategies in the brain metastasis tumor microenvironment.

Brain metastasis is a major contributor to poor prognosis in cancer patients, with therapeutic efficacy severely constrained by the blood-brain barrier and the complex brain microenvironment. Although lipid metabolic reprogramming has been linked to tumor progression across multiple cancer types, its mechanistic involv...

Xue-Fang Huang, Xin-Miao Xian, Hong-Yuan Zhang et al. · 0 citations
Open access Sep 2026

Migrasome-propagated ITGβ3-TGFβ1 circuit orchestrates breast cancer brain metastasis by reprogramming the microglial niche.

OBJECTIVE The dismal prognosis of breast cancer brain metastasis (BCBM) is attributed to a maladapted tumor microenvironment. This study was aimed at deciphering the role of novel intercellular communicators, tumor-derived migrasomes, in driving BCBM progression, with a focus on their ability to co-opt brain-resident m...

Song Wang, Xin-Miao Xian, Guo-Hao Gu et al. · 0 citations

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