Xue-Feng Wang

Imaging and Calibration of Receptor-Specific Cellular Forces Using Biotinylated Ligands.

Covalent conjugation of ligand molecules to force sensors provides a powerful approach to image receptor-transmitted cellular forces. While this strategy is effective for small-molecule ligands, the conjugation process can damage large protein ligands. To address this challenge, we developed a modular mechano-fluoresce...