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Open access Aug 2026

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

ABSTRACT Acute kidney injury (AKI) is a clinical syndrome associated with severe morbidity and high mortality, for which there are no currently effective therapies. Aging, a state associated with Klotho protein decline, is an independent risk factor for AKI development and progression. Here, we report that Klotho‐deriv...

Xiaoyao Zhang, Shih-Hua Lin, Tianyu Wu et al. · 0 citations
Open access Aug 2026

Integrated single-cell and spatial transcriptomic analyses identify a unique subset of pro-fibrotic macrophage in kidney fibrosis.

INTRODUCTION Acute kidney injury (AKI) is a severe clinical syndrome associated with high morbidity and mortality, and it possesses high risk of progression to chronic kidney disease (CKD). Renal infiltration of inflammatory cells, particularly macrophages, plays a key role in driving the progression from AKI to CKD....

Liuyan Xiao, Yinyi Long, Xue Hong et al. · 0 citations

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