Guava Polysaccharide Interventions Ameliorate Delayed Neurocognitive Recovery by Modulating the Gut Microbiota-Arachidonic Acid Metabolism Axis and Attenuating Aβ/Tau Pathology.
Delayed neurocognitive recovery (dNCR) is the most common complication after anesthesia and surgery (A/S) with unclear mechanisms and no effective therapy. Here, we purified a pectin polysaccharide (GP) from guava fruits (Mw 94.516 kDa), featuring a backbone of HG and RG-I domains with side chains of →3,6)-β-d-Galp-(1→...