Xuejun Wang

Lead triggers hepatocyte ferroptosis through coordinated mitochondrial injury and ER stress-mediated autophagic degradation of GPX4.

Lead (Pb) is one of the major heavy metal pollutants that induces multi-organ toxicity. Liver is the primary target of Pb, the exposure of which induces hepatotoxicity by triggering hepatocyte cell death. Ferroptosis, a novel iron-dependent form of regulated cell death, has recently been implicated in a variety of heav...