Xue-Kai Zhang

A single residue in the Gc protein dictates neutralization sensitivity and virulence in SFTSV.

Severe fever with thrombocytopenia syndrome virus (SFTSV), a World Health Organization (WHO) priority pathogen, causes hemorrhagic fever with up to 30% case fatality and lacks approved vaccines or therapeutics. Here, we isolated Gc-specific monoclonal antibodies H2, H4, and H12. H2 potently neutralized endemic Chinese...