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Xue-Lian Wang

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Sep 2026

Sephin1 directly targets PHB2 to activate PINK1-PRKN-dependent mitophagy and alleviate α-synuclein neurotoxicity in Parkinson's disease models.

Parkinson's disease (PD) is a prevalent age-related neurodegenerative disorder characterized by pathological α-synuclein aggregation, mitochondrial dysfunction, and progressive loss of dopaminergic neurons, with no effective disease-modifying treatment available. Sephin1 has been proven to exert protective effects in m...

Xv-shen Ding, Bao Wang, Zheng Han et al. · 0 citations

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