Xue-Min Yin

Mitochondrial dysfunction in sepsis: nutritional strategies for restoring bioenergetic homeostasis

Mitochondrial dysfunction—specifically PDC impairment, mtROS excess, and mitophagy failure—is a core mechanistic axis of sepsis that drives bioenergetic collapse across multiple organ systems and is constrained by biological heterogeneity, lack of routine biomarkers, and inconsistent clinical translation.