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Author

Xue-Tao Li

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Open access Oct 2026

Microenvironment-Triggered Sequentially Targeted Micelles for Dual Regulation of Macrophages and Fibroblast-Like Synoviocytes via ROS-Responsive Rg1 Release and HAP-1-Mediated Celastrol Delivery in Rheumatoid Arthritis Therapy

This novel nanoplatform promotes FLS apoptosis while mitigating local inflammatory responses, providing a promising therapeutic strategy for RA.

Ya-Ni Zhang, Rui-Bo Guo, Ying Zheng et al. · 0 citations
Open access Aug 2026

Microglia-targeted Panax notoginseng polysaccharide nanoparticles alleviate Alzheimer's disease via AMPK-mTOR/HIF-1α-mediated immunometabolic reprogramming

Alzheimer's disease (AD) is increasingly recognized as an immunometabolic disorder characterized by a self-reinforcing cycle of neuroinflammation and glycolytic reprogramming in microglia. Herein, we developed KPBIT@NPs, a microglia-targeted polysaccharide-based nanomedicine. Unlike many conventional nanocarriers that...

Ge Zhang, Liang Kong, Ruihan Guo et al. · 0 citations
Sep 2026

Stepwise progressive dual-regulated micelles enhance the therapeutic efficacy of hepatocellular carcinoma by remodeling the tumor microenvironment.

This system provides a multifunctional traditional Chinese medicine (TCM) nanodelivery strategy for HCC therapy and exhibits sequential synergistic effects combining GRh2-mediated TME remodeling and Ten H-mediated tumor cell elimination.

Mu-Han Chen, Tian-Hua Li, De-Jin Ma et al. · 0 citations
Open access Aug 2026

AB4-Loaded Nanomicelle Hydrogel Promotes Targeting of the Dysregulated Diabetic Wound Microenvironment via Coordinated Multistage Repair

This nanocomposite hydrogel integrating a bioactive carrier with a therapeutic payload to enable coordinated intervention across multiple phases of diabetic wound repair offers a promising strategy for the treatment of chronic diabetic wounds.

Xue Shao, De-Jin Ma, Ya-Ni Zhang et al. · 0 citations

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