Ferroptosis is an iron-dependent regulated cell death driven by lipid peroxide accumulation. This review discusses its dual role in embryonic development. Physiologically, ferroptosis regulates cell fate and tissue remodeling through the synergistic GPX4-GSH and FSP1-CoQ10 pathways. Beyond passive cell death, iron-depe...
Fan Meng, Shi-Long Li, Xue-Ting Wang et al.· Frontiers in Cell and Develo...· 0 citations
The tumor microenvironment (TME) refers to the non-malignant cellular and stromal components present within tumors, which play critical roles in cancer initiation, progression, metastasis, and therapeutic response. Among the diverse cellular constituents of the TME, cancer-associated fibroblasts (CAFs) represent a key...