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Open access Aug 2026

Mechanism Investigation of Sophora davidii Flower Extract Against LPS-Induced Acute Lung Injury Based on Network Pharmacology and Molecular Dynamics Simulation

SDFE can ameliorate LPS-induced ALI by inhibiting leukocyte adhesion and reducing oxidative stress, and Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated that leukocyte adhesion and oxidative stress are two key signaling pathways involved in the therapeutic effects of SDFE against ALI.

Cheng Lin, Xue Wang, Dao-Yuan Li et al. · 0 citations
Open access Sep 2026

Artesunate Targets MBL2 to Modulate the TLR4/NRF2/HO‑1 Axis and Ameliorate Podophyllotoxin‑Induced Liver Injury

Background Drug-induced liver injury (DILI) presents a significant clinical challenge with limited preventive and therapeutic options. Artesunate (ART) holds potential for DILI treatment; however, its precise hepatoprotective mechanisms and direct molecular target(s) remain unclear. Methods We evaluated ART in a podoph...

Ming-Yue Wei, Jun-Jie He, Yan-Zhao Zhang et al. · 0 citations

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