Author

Xue-Wen Li

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Review Open access Sep 2026

Research progress on the pathophysiological mechanisms of pioglitazone-induced heart failure: a review

Pioglitazone is thought to increase the risk of heart failure exacerbation in vulnerable individuals, primarily through fluid retention and plasma volume expansion. However, the precise molecular and cellular mechanisms remain incompletely understood. This narrative review aims to collect, organise, and evaluate curren...

Jian-Li Li, Yi-Fei Zhang, Xue-Wen Li · Frontiers in Cardiovascular... · 0 citations

Open access Sep 2026

Genetic Evidence for a Putative B Cell–Cholate Immunometabolic Axis in Pericarditis: A Mendelian Randomization Study

Background: Pericarditis is an inflammatory heart disease with unclear causal mechanisms. Immune dysregulation is implicated, but observational studies cannot reliably infer causality. Whether plasma metabolites mediate immune-pericarditis pathways remains unknown. Methods: A two-sample Mendelian randomization (MR) stu...

Yi-Fei Zhang, Wu-Xiao Yang, Xue-Wen Li · Biomedicines · 0 citations