Author

Xue-Yan Wu

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Open access Oct 2026

Apoptotic cell overload drives multinucleated giant cell formation after neoadjuvant chemotherapy in colorectal cancer: molecular mechanisms and tumor-suppressive effects

Colorectal cancer is a common digestive malignancy. Neoadjuvant chemotherapy (NAC) can downstage tumors and increase R0 resection rates. In colorectal cancer specimens with favorable pathological regression after NAC, we observed CD68 + multinucleated giant cells (MGCs) preferentially localized in apoptotic cell-...

Jia-Xin Xue, Zhi-Wei Wang, Xiao-Liang Zhang et al. · Cell Death & Disease · 0 citations

Sep 2026

Abstract A039: Epigenetic regulation of cellular heterogeneity and the tumor-immune landscape in pancreatic cancer

Cellular heterogeneity in pancreatic ductal adenocarcinoma (PDAC) poses significant challenges for disease prognosis and limits the effectiveness of therapeutic strategies implemented in recent multicenter subtype-based clinical trials worldwide. A hallmark of PDAC is extensive intratumoral heterogeneity, which is la...

Xue-Yan Wu, L. Klein, M. Tu et al. · Cancer Research · 0 citations