Poly (Lipoic Acid) Nanoparticles With High Blood-Brain Barrier Permeability and Enhanced Anti-Ferroptotic Activity for Ischemic Stroke Treatment.
Lipoic acid (LA) scavenges free radicals and was clinically tested for ischemic stroke. However, the short half-life and weak efficacy in penetrating the blood-brain barrier (BBB) limit its use in the brain. Here, we developed poly (lipoic acid) nanoparticles (pLANs) with a half-life of more than 15 h and a high effici...