Open access
Sep 2026
Cryo-EM structure-based discovery of etravirine as a specific inhibitor of PRMT5/pICln protein-protein interaction for prostate cancer treatment
It is demonstrated that the unique P4I interface is a promising therapeutic target and that etravirine serves as a proof-of-concept lead compound for exploring the potential of P4I-targeted strategies in prostate cancer.
Zhi-Xia Chi, Xue-Yong Xu, Zhi-Hang Shen et al.
· Journal of Enzyme Inhibition... · 0 citations