Author

Xue-Zhong Yu

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Open access Sep 2026

Retinoic acid regulates donor myeloid-derived suppressor cell and colonic dendrite cell reconstitution after allogeneic hematopoietic stem cell transplantation in mice

It is demonstrated that RA participates in regulating donor MDSC and colonic CD103+ DC reconstitution after allogeneic HSCT, and adding RA to the MDSC culture promotes the differentiation of Ly6C-Ly6G+ granulocytic MDSCs.

Xin-Lei Li, Jian-Wei Zheng, Dian Zhou et al. · Frontiers in Immunology · 0 citations

Open access Jul 2026

CAR-T with ICOS costimulation lacks therapeutic efficacy in patients due to strong trogocytosis and failure of expansion 2261203

The ICOS domain promotes trogocytosis and fratricide, explaining the poor persistence and function of ICOS CAR-T cells observed in this trial and raise significant caution for using CAR constructs that rely on ICOS for CAR activation.

Yongxia Wu, Allison Pugel, Katie A. Palen et al. · Journal of Immunology · 0 citations