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Review Open access Sep 2026

NAD+ signaling in Parkinson's disease: molecular mechanisms and therapeutic perspectives

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder worldwide, characterized by the progressive loss of dopaminergic neurons in the substantia nigra, accumulation of α-synuclein (α-syn), mitochondrial dysfunction, and neuroinflammation. Nicotinamide adenine dinucleotide (NAD + ), a cruc...

Tian-Bao Wang, Xue Zhou, Xin-Hua Chen · 0 citations

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