Open access
Jul 2026
Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT
The findings suggest that targeting SLC25A46 represents a rational strategy to improve treatment outcomes in OC patients and highlight the critical role of SLC25A46/MARCHF5/CACT axis in facilitating cell proliferation and ferroptosis evasion in OC cells via activating fatty acid oxidation‐mediated ATP and NADPH production.
Yunge Gao, Jiatao Hao, Xiaohong Zhang et al.
· Advancement of science · 0 citations