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Author

Xuemin Jian

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Review Aug 2026

Metabolic Reprogramming-Driven Neuroimmunoregulation: Key Mechanisms and Therapeutic Opportunities and Challenges in Central Nervous System Disorders.

Central nervous system (CNS) disorders are fundamentally linked to metabolic dysregulation within immune and glial cells. This review provides a systematic synthesis of immunometabolic reprogramming-encompassing glucose, lipid, and amino acid metabolism, and oxidative phosphorylation-in CNS-resident microglia, immunomo...

Nan Li, Yuanyuan Wu, Huiyi Feng et al. · 0 citations
Open access Jul 2026

Machine learning–driven identification of PIM2 kinase inhibitors through QSAR modeling and molecular dynamics simulations

An integrated machine learning–guided computational pipeline was developed to identify potential PIM2 inhibitors by combining quantitative structure–activity relationship (QSAR) modeling, virtual screening, molecular docking, molecular dynamics simulations, and pharmacokinetic prediction, highlighting the potential of...

A. Fahira, M. Shahab, Zaheer Ud Din et al. · 0 citations

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