The Alpha-CRISPR RNA detection system developed in this study integrates AlphaLISA technology with the CRISPR-Cas13a system, achieving significantly enhanced detection sensitivity, demonstrating substantial application potential in fundamental medical research and clinical diagnostics.
Yaofan Lu, Zhen-Ya Cheng, Zheng Wang et al.· ACS Sensors· 0 citations
CTLA-4 blockade with Ipilimumab or Tremelimumab shows promise, especially combined with PD-1/PD-L1 inhibitors, yielding enhanced antitumor immunity in microsatellite instability-high/deficient mismatch repair (MSI-H/dMMR) tumors with high immune infiltration.
Fuyuan Ma, Jingyuan Ma, Yaofan Lu et al.· American Journal of the Medi...· 0 citations
This programmable dual-aptamer amplified luminescent proximity homogeneous assay (AlphaLISA) provides a rapid, homogeneous, and highly adaptable strategy for tumor-derived sEVs analysis, offering promising potential for noninvasive cancer diagnostics.