Author

Xuewen Zhang

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Open access Aug 2026

Discovery of Aurora A/HDAC dual-target inhibitors: broad-spectrum in vitro antitumor activity and in vivo pharmacokinetic limitations.

Z20 is a potent Aurora A/HDAC dual-target inhibitor in vitro, while its pharmacokinetic defects limit clinical potential, which highlights the necessity of optimizing pharmacokinetic profiles for translating in vitro potency to in vivo efficacy.

Li-Rong Zhang, Xuewen Zhang, Jie Zhong et al. · RSC Medicinal Chemistry · 0 citations