Coronavirus Nsp15 endoribonuclease: linking viral RNA regulation to immune evasion and viral fitness
ABSTRACT Coronavirus nonstructural protein 15 (Nsp15) is a conserved uridine-preferring endoribonuclease (EndoU). Studies using mouse hepatitis virus (MHV), SARS-CoV-2, and other coronaviruses have shown that Nsp15 associates with replication–transcription complexes (RTCs) and contributes to viral immune evasion. Struc...