Porcine Serum Amyloid A2 Blocks PRRSV by Directly Targeting Virion-Associated PIP2 and GP5.
Porcine reproductive and respiratory syndrome virus (PRRSV) is a significant pathogen in swine, causing substantial economic losses globally. The host acute-phase response to PRRSV infection and its role in antiviral defense remain poorly understood. In this study, we identify serum amyloid A2 (SAA2) as a key acute-pha...