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Y. Cho

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Open access Aug 2026

SIRT6 Mediates Sterol-Dependent Feedback Regulation of Cholesterol Biosynthetic Genes in Hepatocytes

Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by lipotoxic hepatocellular injury, inflammation, and fibrosis, with excess hepatic cholesterol contributing to disease pathogenesis. While the SCAP–INSIG–SREBP2 pathway classically regulates cholesterol biosynthetic gene expression via sterol sen...

Yeonsoo Kim, Y. Cho, Hyeokjin Lim et al. · 0 citations

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